• Smoked cannabis was superior to placebo in reducing spasticity and pain in patients with MS and,
although generally well tolerated, resulted in statistically significant cognitive effects.
• Larger, long-term studies will be needed to confirm and extend these findings.
Objective
•To assess the short-term safety and efficacy of smoked medicinal cannabis vs. placebo in multiple
sclerosis (MS) patients with spasticity.
Background
• Evidence that cannabis relieves MS-related spasticity is largely anecdotal; potential therapeutic effects, plus
risk and safety issues remain unclear.
Methods
• Single-center, prospective, randomized, placebocontrolled crossover trial in adults with MS and
spasticity. Subjects were randomly assigned to smoke either cannabis (approximately 4% THC) or identical
placebo cigarettes once daily for three consecutive days, with assessments before and after treatment.
Following a washout period of 11 days, subjects crossed over to the opposite condition.
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